The head of a serpent creeping on the ground is easily crushed and bruised, of which it is sensible, and therefore it is careful to hide and cover it.
In the mystical sense, “it”, or “he, Hu”, which is one of the names of God, ( Psalms 102:27 ) ( Isaiah 48:12 ) and here of the Messiah, the eminent seed of the woman, should bruise the head of the old serpent the devil, that is, destroy him and all his principalities and powers, break and confound all his schemes, and ruin all his works, crush his whole empire, strip him of his authority and sovereignty, and particularly of his power over death, and his tyranny over the bodies and souls of men; all which was done by Christ, when he became incarnate and suffered and died, ( Hebrews 2:14 Hebrews 2:15 ) ( Colossians 2:15 ) ( 1 John 3:8 )